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Lead ID 2018

Directors of Scripps HTS | Lead Identification
Profs. Louis Scampavia and This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Lead Identification Division

Under the Scripps Florida umbrella in Jupiter, FL, Lead Identification operates in greater than 6500 ft2 of office and laboratory space. Founded in 2005, Lead ID is comprised of administrative, scientific and engineering personnel with backrounds in both industry and academia. Included in those categories are cell/molecular biologists, biochemists, microbiologists, software programmers, cheminformaticists and compound managers. In addition, Lead ID has access to over 50 medicinal chemists and DMPK/pharmacology techniques at Scripps Florida.

The initial investment for Lead ID was twin Kalypsys-GNF robotic platforms dedicated to high-throughput screening and compound management. Since then it has been awarded multiple NIH grants in addition to other private sources of funding. In 2008, the NIH awarded an $88MM, 6-year MLPCN grant to fund “probe” discovery efforts, a result of the outstanding work of the Scripps’ Translational Research Institute, of which the Lead Identification Division is a primary part.

Scripps Florida

Scripps Florida is a state-of-the-art biomedical research facility located on 30 acres in Jupiter, Florida (Palm Beach County). An additional 70 acres are available for expansion on the adjacent Briger tract in Palm Beach Gardens. Research operations commenced in 2004.

Using the latest research technology, researchers at Scripps Florida focus on basic biomedical research and drug discovery. Over 350 faculty members and scientific, technical, and administrative staff currently work at the 350,000 ft2 complex. The start-up costs of Scripps Florida—a division of The Scripps Research Institute headquartered in La Jolla, California—were supported by a one-time $310 million appropriation of federal economic development funds by the Florida State Legislature. Palm Beach County provided an economic package that included funding for land and construction of the current permanent facility and related costs.

Much of the work at Scripps Florida is dedicated to basic biomedical research, a vital segment of medical research that seeks to decipher the most fundamental processes of life. Additionally, researchers at Scripps Florida are developing advanced technologies, and applying these tools to the discovery of new therapeutic agents for a variety of devastating human diseases, including HIV/AIDS, cancer, depression, diabetes, hepatitis C, leishmaniasis (a tropical and sub-tropical parasitic disease), obesity, prion disease, Parkinson's disease, and diseases of learning and memory including Alzheimer's disease, bipolar disorder, schizophrenia, and autism.

Currently, five academic departments of The Scripps Research Institute are headquartered at Scripps Florida – Cancer Biology, Infectology, Metabolism and Aging, Molecular Therapeutics, and Neuroscience, plus the Translational Research Institute, which consists of two primary departments, Advanced Technologies and Drug Discovery.

A number of Scripps Florida faculty have joint appointments in the Translational Research Institute and an academic department. It is anticipated that additional institute departments will be headquartered at Scripps Florida as it continues to build out academic programs in the biological and chemical sciences.

For more information please visit the Scripps Florida website.

The Scripps Research Institute

While its roots go back to the founding of the Scripps Metabolic Clinic in 1924 by philanthropist Ellen Browning Scripps, The Scripps Research Institute's modern beginnings date to the 1946 establishment of Scripps Clinic and Research Foundation, when a major portion of the Clinic's limited reserves were committed to the construction of a new research facility and to the recruitment of top biomedical scientists.

In 1961, the institution recruited pioneering immunologist Frank Dixon and four of his colleagues from the University of Pittsburgh, researchers who were then contributing insightful observations on the causes and progression of autoimmune disease, to establish a Department of Experimental Pathology in La Jolla.

Their work attracted others and the research program flourished and diversified into biochemistry and microbiology, virology, studies of blood coagulation, and cancer research. From the outset, the guiding philosophy was clinical and basic investigations of the pathogenesis of human disease.

In 1977 the multiple research programs that had developed were formally drawn together into the Research Institute of Scripps Clinic, as it had come to be named, and by the mid-1980s laboratory space had grown to some 300,000 square feet. Major programs in cell and molecular biology and synthetic and bioorganic chemistry had developed, in addition to efforts in immunology and clinically oriented investigations. The Department of Neurobiology was established at the Institute in the 1992.

As the faculty roster has grown, so naturally has the focus and number of areas of research. Today, TSRI scientists are actively investigating biological and chemical aspects of more than 40 diseases, including AIDS, alcoholism, allergy, Alzheimer's disease, cancer, dementia, depression, diabetes, genetic diseases, hepatitis, infectious diseases, multiple sclerosis, renal disease, scleroderma, Sjogren's syndrome, sleep disorders, and diseases involving neural and muscular degeneration.

Among other areas of research that cross specific disease lines are those that involve numerous investigations into the structure and function of proteins; biocatalysis and protein design; the factors, processes and regulation of inflammation; and the form and working of animal and plant cells. All in all, the quality, scope and depth of the science conducted at the Institute enable it to be ranked among the finest scientific research organizations in the world.

In 1991, when Scripps Clinic and Research Foundation and Scripps Memorial Hospitals reaffiliated, the Research Institute became a separate corporation under the parent organization, Scripps Institutions of Medicine and Science. With that change its name became The Scripps Research Institute, a name that will likely be associated with some of the greatest biomedical advances of the decades ahead.

In late 2003, The Scripps Research Institute took a dramatic step in announcing the establishment of a major science center in Palm Beach County, Florida, focusing on biomedical research, technology development and drug design. Funding for the new campus and initial staffing is being supported by the State of Florida via economic development funds as well as local government. Months of intensive discussions with Florida Governor Jeb Bush and state and local officials culminated in the large scale agreement between Scripps Research and the State of Florida. The synergy between the faculties and research conducted at both facilities is expected to lead to significant new developments to improve human health.

For more information please visit the TSRI website.

 

Location

Scripps Florida | Lead Identification Division | 130 Scripps Way | Jupiter | Florida | 33458
(561) 228-2150 | (561) 228-2101
www.scripps.edu/florida

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Scripps Florida  |  130 Scripps Way, Jupiter, FL  33458  |  (561) 228-2000
The Scripps Research Institute  |  10550 North Torrey Pines Road, La Jolla, CA  92037  |  (858) 784-1000