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MLPCN Activities


MLPCN Introduction

Small molecules, often with molecular weights of 500 or below, have proven to be extremely important to researchers to explore function at the molecular, cellular, and in vivo level. Such molecules have also been proven to be valuable for treating diseases, and most medicines marketed today are from this class. A key challenge is to identify small molecules effective at modulating a given biological process or disease state.

The Molecular Libraries Roadmap, through one of its components, the Molecular Libraries Probe Production Centers Network (MLPCN), offers biomedical researchers access to the large-scale screening capacity, along with medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease.

NIH anticipates that these projects will also facilitate the development of new drugs, by providing early stage chemical compounds that will enable researchers in the public and private sectors to validate new drug targets, which could then move into the drug-development pipeline. This is particularly true for rare diseases, which may not be attractive for development by the private sector.

 

SRIMSC

The Scripps Research Institute has been awarded more than $80 million by the National Institutes of Health to greatly expand the work of The Scripps Research Institute Molecular Screening Center, further strengthening the collaborative efforts of teams of scientists at the La Jolla, California and Jupiter, Florida campuses. The six-year grant is the largest ever awarded to Scripps Research.

The Scripps Research Institute Molecular Screening Center will use Lead Identification's high throughput robotics to screen discoveries made in laboratories in La Jolla and Jupiter, as well as other research institutions, against various biological targets. The goal is to uncover "proof-of-concept molecules" that could be useful in developing new treatments for a large number of human diseases.

The Scripps center is one of only four such large centers nationwide. Together with five smaller specialized centers, they comprise the Molecular Libraries Production Centers Network, a part of the NIH's strategic funding plan, the Roadmap Initiative.

 

Lead ID Results

We have screened over 150 assays as part of the MLPCN initiative, encompassing a broad and large variety of targets using numerous different detection technologies and assay formats during this time. A breakdown of public domain HTS campaign types by category can be found in the specific categories of: Target Class, Assay Type, HTS Class and Cell Line.

MLPCN Pipeline
To view a table containing all the public domain campaigns screened at Scripps Florida, please click HERE.

Probe Reports
To view all probe reports generated as part of Lead Identification's MLPCN efforts, please click HERE.

 

Funding Agencies

There are multiple agencies that have funded screening as part of the MLPCN initiative at Scripps Florida.  They are:

National Cancer Institute (NCI)
National Eye Institute (NEI)
National Heart, Lung, and Blood Institute (NHLBI)
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Allergy and Infection Diseases (NIAID)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute on Drug Abuse (NIDA)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Neurogical Disorders and Stroke (NINDS)

Click on the chart below to enlarge it:

pie_funding_small

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